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Teen striker Mason Greenwood will start Manchester United’s Europa League team game against Astana .
The 17-year-old has already made four substitute appearances in the Premier League this season.
England under-21 shield Axel Tuanzebe may start, alongside reserve goalkeeper Sergio Romero and midfielder Fred.
Winger Daniel James misses out after picking up a knock against Leicester.
Even the 21-year-old Welshman, who has scored three goals in five league games this year, combines midfielder Paul Pogba, forward Anthony Martial and shield Luke Shaw on the injury list.
But, midfielder Jesse Lingard is very likely to be involved and has recovered from illness.
Greenwood had an amazing summer for United, scoring in pre-season victories over Inter Milan and Leeds later making his debut in a 2-0 defeat to Arsenal in the Premier League at March.
He’ll begin his first match of the year on Thursday and director Ole Gunnar Solskjaer says he has”grown in the past six months”.
“He is still very young. I remember the kid who only wanted to play along with his teammates in the under-18s,” said Solskjaer. “Now he is knocking on the door along with his desire for soccer has to be increasing.
“I just don’t wish to put too much pressure on him. Mason’s one of the best finishers I have played with a couple of decent ones and I’ve seen.
“If you’re 17, 18, 19 years old, the next game is obviously the most significant one. It doesn’t matter how many you scored.
“There’ll probably be 11 Astana players living the dream – it’s but one of the biggest games of their professions – but I still want it to be a memorable one for our players also.”
Tuanzebe created his debut in a 4-0 win over Wigan in the FA Cup at January 2017 and has created eight first-team appearances in total for Manchester United.
However he has played only 1 moment in the Premier League this year, coming on as a late substitute in Saturday’s narrow victory over Leicester.
“It is a part of the practice of developing. I recall my glimpses at the first staff at 19 – it wasn’t to be but today I am 21 and things are starting to open up more. I know where I want to be moving,” explained Tuanzebe.
Solskjaer added:”In case you don’t throw them in, you don’t know exactly what you’ve got. I really don’t find any method of doing so.
“I’ve always done it wherever I have been, that’s my belief as a coach, to provide a chance, an opportunity.”
Despite attaining the quarter-finals of their Champions League last season, United entered the Europa League following a sixth-place ending from the Premier League.
They won this contest and haven’t failed to go past the group stages.
It is the first time they come up against Kazakh winners Astana, that are competing at the Europa League for the fourth successive season.
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